Lecture Tuesday September 11: Male Reproductive histology

A. Seminiferous tubules

- Spermatogenesis -
Spermatogonia to spermatids
1. Spermatogonia (diploid) > MITOSIS > spermatogonia and a Primary Spermatocyte (diploid)
2. Primary Spermatocyte > MEIOSIS I > Secondary Spermatocyte (haploid) > MEIOSIS II > Spermatids (haploid)

- Spermiogenesis -
Spermatids to spermatozoa (haploid cells). Primarily a change in structure.



*BE ABLE TO IDENTIFY THE DIFFERENT CELL TYPES IN A HISTOLOGICAL SECTION OF THE SEMINIFEROUS TUBULE*

B. Sertoli cells - are support cells that form the Blood-Testis Barrier.
Secretory Products:
1. ABP (androgen binding protein) in response to FSH (follicle stimulating hormone). Concentrates testosterone to a level that promotes spermiogenesis.
2. Inhibin that inhibits FSH secretion by the pituitary gland.

Leydig cells - produce testosterone in response to LH (leutinizing hormone) from the pituitary gland.

B. Prostate Gland
3 zones:
- Transitional zone surrounding the urethra (benign prostatic hypertrophy)
- Central zone adjacent to transitional zone surrounding ejaculatory ducts
- Peripheral zone makes up most of the volume and is the primary site of cancer development.

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